Dr. Eric Daiter, MD - Causes of Miscarriages and Available Treatments

An evaluation for known causes of recurrent pregnancy loss is usually initiated after 2 or 3 consecutive pregnancy losses. The tremendous emotional impact of each loss may encourage an evaluation sooner than later. A full evaluation includes

Demonstration of a normally shaped uterine cavity (by either hysterosalpingogram or hysteroscopy)
Evaluation for a hormonal deficiency in progesterone production (by either endometrial biopsy or bloodwork)
Analysis of both the maternal and paternal chromosomes (by bloodwork)
Laboratory testing for immunologic causes of pregnancy loss (by bloodwork)
Taking a history for maternal disease states, environmental or other toxin exposure

If a full evaluation is completed on couples with either 2 or 3 consecutive losses there will still be about 50% (1 of 2) of couples with “unexplained” recurrent pregnancy loss. That is, roughly half of couples seem to have a reason for recurrent loss that is beyond modern medicine's ability to diagnose this cause. This can be frustrating for both the couple and the physician. In this situation, the couple will at least know that potentially repairable pathology has been ruled out. The couple can then elect to enroll in experimental protocols designed to further our knowledge of recurrent pregnancy loss. In my experience, these experimental treatments often result in reproductive success despite limited knowledge on why they work.

Available Case Reports:

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